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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
19.39
Human Site:
Y1238
Identified Species:
30.48
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
Y1238
E
E
T
M
P
S
P
Y
G
R
R
I
I
P
E
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
Y1246
E
E
T
M
P
S
P
Y
G
R
R
I
I
P
E
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
Y1232
E
E
T
M
P
S
P
Y
G
R
R
V
I
P
E
Dog
Lupus familis
XP_534241
2041
231068
Y1656
E
E
T
M
P
S
P
Y
G
R
R
I
V
P
E
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
Y1226
E
E
T
M
P
S
P
Y
G
R
R
I
V
P
E
Rat
Rattus norvegicus
P41516
1526
173202
S1161
T
L
K
K
K
T
P
S
D
L
W
K
E
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
G1542
E
T
M
P
S
P
Y
G
R
R
I
I
P
Q
I
Chicken
Gallus gallus
O42131
1627
183228
G1244
E
T
M
P
S
P
F
G
R
R
I
V
P
Q
I
Frog
Xenopus laevis
NP_001082502
1579
178601
H1210
Q
E
I
M
P
S
P
H
G
R
R
V
I
P
R
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
F1237
E
E
T
L
P
S
P
F
G
R
R
V
E
P
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
E1082
R
I
K
M
E
D
A
E
Q
A
D
E
E
D
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
E1155
L
A
A
V
A
V
E
E
D
E
A
I
S
S
A
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
M1083
N
N
Q
A
R
F
I
M
E
K
I
D
G
K
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
S1108
I
L
V
D
P
E
S
S
S
S
Y
I
P
G
S
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
E1063
G
F
P
R
F
N
K
E
G
K
P
Y
Y
G
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
93.3
93.3
N.A.
93.3
6.6
N.A.
20
13.3
66.6
66.6
N.A.
13.3
N.A.
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
20
20
86.6
93.3
N.A.
13.3
N.A.
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
7
7
0
7
0
0
7
7
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
7
0
0
14
0
7
7
0
14
0
% D
% Glu:
54
47
0
0
7
7
7
20
7
7
0
7
20
0
40
% E
% Phe:
0
7
0
0
7
7
7
7
0
0
0
0
0
0
0
% F
% Gly:
7
0
0
0
0
0
0
14
54
0
0
0
7
14
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
7
7
7
0
0
0
7
0
0
0
20
47
27
0
14
% I
% Lys:
0
0
14
7
7
0
7
0
0
14
0
7
0
7
0
% K
% Leu:
7
14
0
7
0
0
0
0
0
7
0
0
0
0
7
% L
% Met:
0
0
14
47
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
7
7
0
0
0
7
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
7
14
54
14
54
0
0
0
7
0
20
47
0
% P
% Gln:
7
0
7
0
0
0
0
0
7
0
0
0
0
14
7
% Q
% Arg:
7
0
0
7
7
0
0
0
14
60
47
0
0
0
7
% R
% Ser:
0
0
0
0
14
47
7
14
7
7
0
0
7
7
14
% S
% Thr:
7
14
40
0
0
7
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
7
7
0
7
0
0
0
0
0
27
14
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
34
0
0
7
7
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _